USP14 competitively binds to FBXW7 to stabilize MTDH and promotes metastasis and drug resistance of head...

Proceedings of the National Academy of Sciences, Volume 123, Issue 34, August 2026. SignificanceThe metadherin (MTDH) gene encodes astrocyte elevated gene-1 (AEG-1)/lysine-rich CEACAM1 coisolated protein (LYRIC) in huma...

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Published: 2026-08-30 • Permanent link

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SignificanceThe metadherin (MTDH) gene encodes astrocyte elevated gene-1 (AEG-1)/lysine-rich CEACAM1 coisolated protein (LYRIC) in humans, and it is markedly upregulated in ma...

Why It Matters

Why it matters: this intelligence reflects a shift that researchers and analysts should follow closely.

Source: https://www.pnas.org/doi/abs/10.1073/pnas.2504068123?af=R

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